POVIDONE IODINE SOLUTION 10% W/V USP

DESCRIPTION:
Povidone Iodine 10% Solution is an antiseptic medicine used to prevent and treat minor wounds and skin infections. It kills sensitive organisms like bacteria, fungus, protozoa, and spores present on the skin. It is also used to sanitize skin before a surgical procedure is performed.

COMPOSITION:
Povidone Iodine USP 10 % w/v
(Available Iodine1% w/v)
Aqueous base Q.S.

PHARMACOLOGY:
Mechanism of Action
Povidone iodine is an iodophore antiseptic and is a microbicidal drug. It releases iodine from its complex and produces pharmacological actions. The released iodine produces antiseptic actions. Iodine is highly reactive with surrounding and has strong oxidizing effect on functional groups of amino acids (-NH 2, -SH etc.), Nucleotides, and fatty acids (double bond of unsaturated fatty acids). Interaction of Iodine with these groups in a cell results in disintegration of the cytoplasm, enzyme denaturation, loss of integrity in the bacterial cell membrane and fungal cell wall .These will leads to destruction of microbial protein and DNA and finally kills the microbes.

Pharmacokinetics
Absorption
It is poorly absorbed through intact skin but absorption is enhanced through denuded skin.

Distribution
Povidone-Iodine is intended for topical application and has no volume of distribution.

Metabolism
Povidone-Iodine is not absorbed or metabolized.

Excretion
Povidone-Iodine is intended for topical application and is not eliminated.

CONTRAINDICATIONS:
Known or suspected iodine hypersensitivity to iodine. Regular use is contraindicated in patients or users with thyroid disorders (in particular nodular colloid goitre, endemic goitre and Hashimoto’s thyroiditis). Povidone-Iodine is not recommended for regular use in neonates and is contraindicated in very low birth weight infants (below 1500 grams). Special caution is needed when regular applications to broken skin are made to patients with preexisting renal insufficiency. Regular use should be avoided in patients on concurrent lithium therapy. This preparation is flammable and caution is advised during surgical procedures involving hot wire cautery or diathermy.

DOSAGE AND ADMINISTRATION:
To be applied undiluted in preoperative skin disinfection and general antiseptic. This solution is for external use only.

OVERDOSE:
Contact a doctor if you have used too much of povidone iodine or have accidently swallowed the medicine. Symptoms of overdose may include a metallic taste in the mouth, increased salivation, burning or pain sensation in the mouth or throat, diarrhea etc. Immediate medical intervention may be needed if the overdose is severe.

WARNING:
Severe skin allergy
Use of this medicine should be discontinued if you experience a skin rash, hive, or severe itching.

External use only
This medicine is for external use only and should not be applied in the eyes.

Short-term use
This medicine should be used for short duration only as the risk of side effects increase significantly on prolonged usage.

Kidney disease
This medicine should be used with caution in patients having a kidney disease or an impairment of the normal kidney function.

Deep wounds
This medicine should not be used when the wound is very deep or puncture wounds.

Burns
This medicine should not be used in case of serious burns.

DRUG INTERACTION:
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.

Interaction with Alcohol
Description
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Instructions
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Interaction with Medicine Lithium Collagenase

Disease interactions
Thyroid disorders
This medicine should be used with caution in patients having an active thyroid hormone disorder. Any instance indicative of an imbalance in thyroid hormone should be reported to the doctor.

Food interactions
Information not available.

Lab interactions
Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.