OMYCIN 300
CLINDAMYCIN HYDROCHLORIDE CAPSULES USP 300 MG
COMPOSITION
Each hard gelatin capsule contains :
Each hard gelatin capsule contains :
| Clindamycin Hydrochloride | USP |
| Eq. to Clindamycin | 300 mg |
| Excipients | Q.S. |
PHARMACOLOGY
Clindamycin is used to treat a wide variety of bacterial infection. It is an antibiotic that works by stopping the growth of bacteria. This antibiotic treats only bacterial infections.
MACHANISM OF ACTION
Mechanism of Action Clindamycin inhibits bacterial protein synthesis by binding to the 23S RNA of the 50S sub unit of the ribosome. Clindamycin is bacteriostatic. Resistance to clindamycin is most often casued by modification of specific bases of the 23S ribosomal RNA.
PHARMA COKINTICES
Absorption
After oral administration clindamycin is absorbad quickly and almost completely (>90%). The absorption is not affected by food. The peak plasma concentration is achieved within approximately 45 minutes after oral administration. The bioavailability is non-linear and decreases with increasing doses. Following a 600 mg dose the absolute bioavailability is 53 = 14%.
